News: CBE

Synthetic biology to discover kratom natural product biosynthetic pathways for biased analgesic development

Prof. Sijin Li's Project Summary Opioid alternative analgesics that would kill pain potently without the respiratory side effect will be of specific importance in addressing the opioid crisis. The medicinal herb kratom (Mitragyna speciosa) produces natural products (mitragynine and 7-hydroxymitragynine) that selectively activate analgesia only, which are promising “biased” opioid alternatives. Elucidating the kratom biosynthetic pathway composed of enzymes catalyzing sequential reactions toward the syntheses of mitragynine, 7-hydroxymitragynine, or other kratom products is important to the... Read more