The Daniel Research Group earns the cover of ACS Infectious Disease Journal for their work on SARS-CoV-2

ACS Journal

This work investigates the activation requirements for SARS-CoV-2 host-cell entry. SARS-CoV-2 entry is mediated by its spike (S) protein, and previous studies indicate that it has a novel S1/S2 site not before seen in SARS-like CoV that can be cleaved by furin-like proteases. Here, we show that S1/S2 cleavage expands SARS-CoV-2 entry into Calu-3 cells, a model lung cell line, but reduces SARS-CoV-2 entry into Vero E6, a model cell culture line. This S1/S2 cleavage was observed to be cleaved by proteases beyond furin and as a result of weak furin specificity, we offer thoughts on how it originated from ancestor bat viruses.  

Other Articles of Interest