ChemE Car Team wins AICHE Northeast Regional competition with two nearly perfect runs! The ChemE Car Competition is a biannual design challenge in which engineering students must design a small car... Read more about Cornell ChemE Car Team wins 2021 AIChE Northeast Regional Competition
The Daniel Research Group earns the cover of ACS Infectious Disease Journal for their work on SARS-CoV-2
This work investigates the activation requirements for SARS-CoV-2 host-cell entry. SARS-CoV-2 entry is mediated by its spike (S) protein, and previous studies indicate that it has a novel S1/S2 site not before seen in SARS-like CoV that can be cleaved by furin-like proteases. Here, we show that S1/S2 cleavage expands SARS-CoV-2 entry into Calu-3 cells, a model lung cell line, but reduces SARS-CoV-2 entry into Vero E6, a model cell culture line. This S1/S2 cleavage was observed to be cleaved by proteases beyond furin and as a result of weak furin specificity, we offer thoughts on how it originated from ancestor bat viruses.