Moonsoo M. Jin
Moonsoo Jin received an undergraduate degree from Seoul National University, Seoul, Korea and both of his master and doctoral degrees at MIT. Then he moved to Harvard Medical School for his postdoctoral training in what can be broadly defined as protein engineering and design. In 2006, he joined Cornell University as a faculty in the department of Biomedical Engineering. His lab uses multi-scale, interdisciplinary approaches to developing proteins for therapy and diagnosis applications. He received New Investigator Recognition Award by Orthopaedic Research Society (2003), Scientist Development Grant from the American Heart Association (2008), and NIH Transformative R01 Grants (2009).
We are studying protein-protein interactions that occur at virus entry into host cells and escape from endosome into cytosol, between cellular adhesion molecules in the immune system, and tumor development. Through this understanding, we are particularly interested in developing therapeutic molecules in passive immunotherapy to treat infectious diseases, drugs that would inhibit aberrant infiltration of immune cells in autoimmunity, and nanoparticles that would detect and kill tumors in the body. We utilize diverse molecular biology, biochemistry, and biophysical tools and develop unique protein engineering platforms implemented by directed evolution and rational design. Some of the novel proteins are being utilized for detection of diseased cells and tissues by whole body optical imaging, MRI, CT, and PET.
- 2011. "Tunable Physiologic Interactions of Adhesion Molecules for Inflamed Cell-selective Drug Delivery." Biomaterials 32: 3487-98. .
- 2010. "Combinatorial Libraries Against Libraries for Selecting Neoepitope Activation-specific Antibodies." PNAS 107: 6252-7. .
- 2010. "Cubic Mesoporous Graphitic Carbon(IV) Nitride: An All-in-one Chemosensor for Selective Optical Sensing of Metal Ions." Angewandte Chemie International Edition English 49: 9706-10. .
- 2010. "Engineering of Single Ig Sperfamily Domain of Intercellular Adhesion Molecule 1 (ICAM-1) for Native Fold and Function." Journal of Biological Chemistry 285: 15906-15. .
- 2010. "Self-assembled Nanoplatform for Targeted Delivery of Chemotherapy Agents Via Affinity-regulated Molecular Interactions." Biomaterials 31: 7766-75. .
Selected Awards and Honors
- Transformative Grant (NIH) 2009
- Scientist Development Grant (American Heart Association) 2008
- New Investigator Recognition Award (Orthopedic Research Society) 2002
- Merit Scholarship 1991
- BS (Mechanical Engineering), Seoul National University, 1997
- MS (Mechanical Engineering), Massachusetts Institute of Technology, 1999
- Sc D (Mechanical Engineering - Bioengineering), Massachusetts Institute of Technology, 2002
- Post-doc (Structural biology, Protein engineering), Harvard Medical School, 2006