Christopher A. Alabi
Christopher Alabi began his research career as an undergraduate student under the direction of Professor David Schuster at New York University. Upon receiving his B.S. in Chemistry from New York University and B.E. in Chemical Engineering from Stevens Institute of Technology, he went on to pursue a graduate degree in Chemistry at California Institute of Technology with Professor Mark Davis. There, he carried out a two-part dissertation on proton conductive membranes and targeted nanoparticle delivery. He then moved to MIT in 2009 and served as NIH Postdoctoral Fellow with Professor Langer and Anderson. Chris joined the Cornell faculty in the summer of 2013 as an Assistant Professor in the School of Chemical and Biomolecular Engineering. His research focuses on surface characterization of drug loaded nanoparticles and enhancing intracellular RNA transport and delivery.
The primary interest of the Alabi group is to facilitate the development and translation of nanoparticle therapeutics by elucidating the underlying principles that dictate their macromolecular interactions and transport in complex biological environments. To this end, our research will fall along two major themes: 1) the development of a multiparametric characterization tool that enables functional analysis of the nanoparticle surface composition. This surface characterization should facilitate our understanding of the macromolecular properties that drive in vivo biodistribution patterns, which can ultimately be leveraged towards the rational design of tissue specific therapeutics. 2) the design of molecular/polymeric conjugates that can aid our understanding of intracellular trafficking pathways and facilitate intracellular transport from endocytic vesicles to the desired intracellular target location.
Christopher Alabi teaches ChemE 4180: an elective class for chemical, biomedical and biological engineering students at the senior and MEng levels.
- 2012. "FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA-Nanocomplexes." ACS Nano 6 (7): 6133-6141. .
- 2012. "Attacking the genome: emerging siRNA nanocarriers from concept to clinic." Curr. Opin. Pharmacol. 12: 1-7. .
- 2013. "Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles." Integrative Biology 5 (1): 224. .
- 2013. "Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling." Nat. Biotech. 31 (7): 653-658. .
- 2013. "Multi-parametric approach for the evaluation of lipid nanoparticles for siRNA delivery." PNAS, published online ahead of print July 23, 2013 110 (32): 12881-12886. .
Selected Awards and Honors
- Herb Fried Award 2004
- Distinguished Chemical Engineering Student Award 2004
- Founders Day Award, Honors Scholar 2004
- Benjamin J. Rosen Fellowship 2004
- NIH Ruth Kirschstein NRSA Postdoctoral Fellowship (National Institute of Health) 2010
- BS (Chemical Engineering), Stevens Institute of Technology, 2004
- BS (Chemistry), New York University, 2004
- Ph D (Chemistry), California Institute of Technology, 2009
- NIH Postdoctoral Fellow Massachusetts Institute of Technology, 2013