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DeLisa lab creates therapeutic proteins in a 'snap'

Tuesday, August 26, 2014

Production of eukaryotic proteins in bacteria is limited by the specificity of the bacterial oligosaccharyltransferase enzymes that perform N-linked glycosylation. To address this challenge, Anne Ollis, a postdoc in the DeLisa research group, invented a new technique, called ‘GlycoSNAP’, that greatly simplifies the study of these enzymes, leading to mutants with relaxed specificity. Her efforts are described in Nature Chemical Biology, published online Aug. 17, and could be a big step forward in using bacteria to engineer therapeutic proteins, such as monoclonal antibodies, that require glycosylation for proper function.

The Cornell Chronicle also featured the work in an article by Anne Ju.

Nature Chemical Biology article:

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1609.html

Cornell Chronicle story:

http://news.cornell.edu/stories/2014/08/new-tool-identifies-therapeutic-proteins-snap

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